Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Effect of norepinephrine dosage on mortality in patients with septic shock. |
Journal | Formal name:Journal of intensive care Abbreviation:J Intensive Care ISSN code:2052-0492(Print)2052-0492(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 6,pp.12 |
Papers・Author | Yamamura Hitoshi, Kawazoe Yu, Miyamoto Kyohei, Yamamoto Tomonori, Ohta Yoshinori, Morimoto Takeshi |
Publication date | 2018/02 |
Papers・Description | Background:Use of high-dose norepinephrine is thought to have an immunosuppressive action that increases mortality. This study aimed to evaluate the correlation between norepinephrine dosage and prognosis of patients with septic shock.Methods:This study was a nested cohort of the DExmedetomidine for Sepsis in Intensive Care Unit Randomized Evaluation (DESIRE) trial. We evaluated 112 patients with septic shock and an initial Sequential Organ Failure Assessment Cardiovascular (SOFA-C) category score> 2 and initial lactate level> 2 mmol/L. We divided the patients into two groups according to the norepinephrine dosage administered over the initial 7 days: high dose (≥ 416 μg/kg/week) (H group,nResults:Patient characteristics appeared to be similar between the two groups except for the SOFA-C score and fibrinogen degradation product level. The cumulative incidence of death at 28 days was 29.9% (16 patients) in the L group and 29.7% (15 patients) in the H group (pConclusions:No statistically significant difference was observed in 28-day mortality between patients with septic shock treated with high-dose norepinephrine compared with those treated with low-dose norepinephrine. However, the number of ventilator-free days in the L group was higher than that in the H group.Trial registration:clinicaltrials.gov Identifier: NCT01760967 Date of trial registration: January 4, 2013. |
DOI | 10.1186/s40560-018-0280-1 |
PMID | 29497535 |