Faculty Information |
|
Article types | Case report |
Language | English |
Refereed paper | Refereed |
Title | A potential drug interaction between phenobarbital and dolutegravir: A case report. |
Journal | Formal name:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Abbreviation:J Infect Chemother ISSN code:1437-7780(Electronic)1341-321X(Linking) |
Domestic / Foregin | Domestic |
Volume, Number, Page | 24(6),pp.476-478 |
Papers・Author | Hikasa Shinichi, Sawada Akihiro, Seino Hitomi, Shimabukuro Shota, Hideta Kyoko, Uwa Noriko, Higasa Satoshi, Tokugawa Tazuko, Kimura Takeshi |
Publication date | 2018/06 |
Papers・Description | In this report, we describe a human immunodeficiency virus (HIV)-infected patient in whom changes in phenobarbital (PB) dosage resulted in associated changes in plasma concentrations of dolutegravir (DTG). His plasma concentrations of DTG were 0.934, 0.584, 1.003 and 3.25 μg/mL, respectively, with concomitant daily PB doses of 40, 70, 30 and 0 mg, respectively. This case suggests that PB can lead to a remarkable reduction in the plasma concentration of DTG in a dose-dependent manner. |
DOI | 10.1016/j.jiac.2017.12.022 |
PMID | 29415844 |