教員業績データベース |
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論文種別 | 症例報告 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | A potential drug interaction between phenobarbital and dolutegravir: A case report. |
掲載誌名 | 正式名:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 略 称:J Infect Chemother ISSNコード:1437-7780(Electronic)1341-321X(Linking) |
掲載区分 | 国内 |
巻・号・頁 | 24(6),pp.476-478 |
著者・共著者 | Hikasa Shinichi, Sawada Akihiro, Seino Hitomi, Shimabukuro Shota, Hideta Kyoko, Uwa Noriko, Higasa Satoshi, Tokugawa Tazuko, Kimura Takeshi |
発行年月 | 2018/06 |
概要 | In this report, we describe a human immunodeficiency virus (HIV)-infected patient in whom changes in phenobarbital (PB) dosage resulted in associated changes in plasma concentrations of dolutegravir (DTG). His plasma concentrations of DTG were 0.934, 0.584, 1.003 and 3.25 μg/mL, respectively, with concomitant daily PB doses of 40, 70, 30 and 0 mg, respectively. This case suggests that PB can lead to a remarkable reduction in the plasma concentration of DTG in a dose-dependent manner. |
DOI | 10.1016/j.jiac.2017.12.022 |
PMID | 29415844 |