教員業績データベース |
|
論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Proposal of a New Preoperative Prognostic Model for Solitary Hepatocellular Carcinoma Incorporating18F-FDG-PET Imaging with the ALBI Grade |
掲載誌名 | 正式名:Annals of surgical oncology 略 称:Ann Surg Oncol ISSNコード:1534-4681(Electronic)1068-9265(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 25(2),pp.542-9 |
著者・共著者 | Yoh Tomoaki, Seo Satoru, Ogiso Satoshi, Kawai Takayuki, Okuda Yukihiro, Ishii Takamichi, Taura Kojiro, Higashi Tatsuya, Nakamoto Yuji, Hatano Etsuro, Kaido Toshimi, Uemoto Shinji |
発行年月 | 2018/02 |
概要 | BACKGROUND:Existing prognostic systems were not developed using only objective variables available preoperatively, and therefore do not provide ideal prognostication for patients undergoing hepatectomy for hepatocellular carcinoma (HCC). We aimed to develop a preoperative prognostic model using objective variables involving two parameters:18METHODS:This study included 207 consecutive patients with solitary HCC who underwent18RESULTS:The 5-year overall survival (OS) and disease-free survival (DFS) rates were 58.6% and 28.8%, respectively. Multivariate analysis of OS identified TNR ≥ 2 (hazard ratio [HR]1.743, 95% confidence interval [CI]1.114-2.648, p = 0.016) and ALBI grade 2 (HR 1.966, 95% CI 1.349-2.884, p < 0.001) as the only significant prognostic factors; tumor diameter and tumor markers were not significant. Patients were divided into low- (TNR < 2 and ALBI grade 1), intermediate- (TNR < 2 and ALBI grade 2, or TNR ≥ 2 and ALBI grade 1), and high-risk (TNR ≥ 2 and ALBI grade 2) groups, which differed significantly in terms of survival (5-year OS: 75.7, 49.6, and 27.3%, respectively, p < 0.001; 5-year DFS: 37.0, 24.9, and 13.6%, respectively, p < 0.001). Compared with other staging systems, our model had the best discriminatory ability (corrected Akaike information criteria 1054.8, p < 0.001) and homogeneity (likelihood ratio Chi square value 27.6, p < 0.001).CONCLUSION:A preoperative prognostic model incorporating18 |
DOI | 10.1245/s10434-017-6262-z |
PMID | 29168098 |