教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs. |
掲載誌名 | 正式名:Cell reports 略 称:Cell Rep ISSNコード:2211-1247(Electronic) |
掲載区分 | 国外 |
巻・号・頁 | 19(8),pp.1614-30 |
著者・共著者 | Yoshinaga Masanori, Nakatsuka Yoshinari, Vandenbon Alexis, Ori Daisuke, Uehata Takuya, Tsujimura Tohru, Suzuki Yutaka, Mino Takashi, Takeuchi Osamu |
発行年月 | 2017/05 |
概要 | Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we show that the endonuclease Regnase-1 is critical for the degradation of mRNAs involved in iron metabolism in vivo. First, we demonstrate that Regnase-1 promotes TfR1 mRNA decay. Next, we show that Regnase-1-/- |
DOI | 10.1016/j.celrep.2017.05.009 |
PMID | 28538180 |