教員業績データベース |
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論文種別 | 総説 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Mechanisms of aortic stenosis. |
掲載誌名 | 正式名:Journal of cardiology 略 称:J Cardiol ISSNコード:1876-4738(Electronic)0914-5087(Linking) |
掲載区分 | 国内 |
巻・号・頁 | 71(3),pp.215-20 |
著者・共著者 | Akahori Hirokuni, Tsujino Takeshi, Masuyama Tohru, Ishihara Masaharu |
発行年月 | 2018/03 |
概要 | The pathobiology of degenerative aortic valve stenosis (AS) is complex and involves multiple features such as fibrosis, inflammation, oxidative stress, angiogenesis, hemorrhage, and osteogenic differentiation. We summarize the mechanism of valve calcification and angiogenesis which is necessary for calcifying processes. A promising therapeutic target is nuclear factor (NF)-κB which activates bone morphogenetic protein (BMP)2 via interleukin-6. BMP2 activates Wnt signaling via msh homeobox 2 causing osteogenic differentiation. BMP2 also activates Runx2/Cbfa1 which is an osteoblast-specific transcription factor. Signals in the hypoxia-inducible factor-2 axis activated by the NF-κB signaling pathway also play important role in calcifying processes including angiogenesis. The reason why angiogenesis takes place in avascular valves is still unknown, but it is likely angiogenesis and angiogenesis-related hemorrhage play critical roles in the progression of AS. |
DOI | 10.1016/j.jjcc.2017.11.007 |
PMID | 29258711 |