教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Intravenous Corticotropin-releasing Hormone Administration Increases Esophageal Electrical Sensitivity in Healthy Individuals. |
掲載誌名 | 正式名:Journal of neurogastroenterology and motility 略 称:J Neurogastroenterol Motil ISSNコード:2093-0879(Print)2093-0879(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 23(4),pp.526-532 |
著者・共著者 | Yamasaki Takahisa, Tomita Toshihiko, Takimoto Mayu, Kondo Takashi, Tozawa Katsuyuki, Ohda Yoshio, Oshima Tadayuki, Fukui Hirokazu, Watari Jiro, Miwa Hiroto |
発行年月 | 2017/10 |
概要 | Background/Aims:When a person is experiencing stress, corticotropin-releasing hormone (CRH) can modulate gut physiologies, such as visceral sensation or gastrointestinal motility, and its intravenous administration mimics stress-induced physiological changes. However, the influence of CRH on the esophagus is yet unknown. Accordingly, we investigated whether intravenous CRH administration increases esophageal sensitivity to electrical stimulation in healthy Japanese subjects.Methods:Twenty healthy subjects were recruited. We quantified the initial perception threshold (IPT) every 15 minutes after CRH injection. Venous blood was collected with a cannula, and both plasma adrenocorticotropic hormone (ACTH) and cortisol were measured at pre-stimulation, 0, 30, 60, 90, and 120 minutes. The results from each time point were compared against a baseline IPT obtained before electrical stimulation was initiated.Results:When compared to the baseline IPT value (16.9 ± 4.5), CRH significantly decreased electrical threshold of the esophagus at 30, 45, 60, 75 minutes (14.1 ± 4.2, 13.1 ± 5.0, 12.1 ± 5.7, 14.0 ± 5.8 minutes, P < 0.01, respectively) after CRH injection, suggesting that CRH increased esophageal sensitivity to the electrical stimulus. CRH also significantly increased plasma ACTH levels at 30 minutes (50.3 ± 17.7, P <0.01), and cortisol levels at 30 minutes (22.0 ± 6.7 minutes, P <0.01) and 60 minutes (20.3 ± 6.7 minutes, P < 0.01) after CRH injection, when compared to the pre-stimulation ACTH and cortisol values.Conclusion:Intravenous CRH administration increased esophageal electrical sensitivity in normal subjects, emphasizing the important role of stress in esophageal sensitivity. |
DOI | 10.5056/jnm17067 |
PMID | 28992676 |