Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer? |
Journal | Formal name:Gastroenterology research and practice Abbreviation:Gastroenterol Res Pract ISSN code:1687-6121(Print)1687-6121(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 2017,pp.4653250 |
Papers・Author | Tomita Toshihiko, Mori Sumire, Tozawa Katsuyuki, Arai Eitatsu, Tano Nobuo, Oka Hideo, Kim Yongmin, Abe Takashi, Ohda Yoshio, Oshima Tadayuki, Fukui Hirokazu, Watari Jiro, Miwa Hiroto |
Publication date | 2017/08 |
Papers・Description | Objective:The percentage of patients with nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin- (LDA-) induced ulcers who complain of gastrointestinal symptoms has generally been considered to be low. The aim of this study was to examine and compare the symptoms and quality of life (QOL) at peptic ulcer onset.Methods:This study involved 200 patients who were confirmed by endoscopy to be in the acute stage of gastroduodenal ulcer (A1-H1). Patients completed a self-administered questionnaire (Global Overall Symptom score and SF-8) at ulcer onset, and data were compared between NSAIDs/LDA ulcers and non-NSAIDs/LDA ulcers.Results:The upper gastrointestinal symptoms score was significantly lower for patients using LDA only (20.5 ± 9.4 in the nonusing group, 19.6 ± 8.6 in the NSAIDs-only group, 16.7 ± 11.6 in the LDA-only group, and 18.5 ± 7.2 in the NSAIDs/LDA group, P<0.05). The QOL score (physical summary) was significantly lower in the NSAID group (42.1 ± 9.9) than in the nonusing group (47.6 ± 7.6) (P<0.05). Patients' characteristics showed no significant differences among the groups, with the exception of age.Conclusion:The severity of upper abdominal symptoms at peptic ulcer onset was similar between NSAID users and nonusers. |
DOI | 10.1155/2017/4653250 |
PMID | 29129973 |