教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Comparison of angioscopic findings among second-generation drug-eluting stents. |
掲載誌名 | 正式名:Journal of cardiology 略 称:J Cardiol ISSNコード:1876-4738(Electronic)0914-5087(Linking) |
掲載区分 | 国内 |
巻・号・頁 | 70(3),pp.297-302 |
著者・共著者 | Nishimoto Yuji, Ueda Yasunori, Sugihara Ryuta, Murakami Ayaka, Ueno Keisuke, Takeda Yasuharu, Hirata Akio, Kashiwase Kazunori, Higuchi Yoshiharu, Yasumura Yoshio |
発行年月 | 2017/09 |
概要 | BACKGROUND:First-generation drug-eluting stents (DES) have reduced short-term stent failure as compared to bare-metal stents due to the inhibition of neointima hyperplasia, but instead increased the risk of very-late stent failure. Although better outcomes have been reported for second-generation DES than for first-generation DES, the difference in the angioscopic findings at 1-year follow-up has not been adequately elucidated among second-generation DES.METHODS:Consecutive 161 patients who received angioscopic examination at 1 year after implantation of second-generation DES, i.e. Nobori biolimus-eluting stents (Terumo, Tokyo, Japan) (N-BES, n=25), Xience everolimus-eluting stents (Abbot Vascular, Santa Clara, CA, USA; X-EES, n=95), or Resolute zotarolimus-eluting stents (Resolute Integrity; Medtronic, Minneapolis, MN, USA; R-ZES, n=41), in de novo native coronary lesions were analyzed.RESULTS:Maximum neointima coverage grade (N-BES, 0.9±0.3; X-EES, 1.2±0.4; R-ZES, 1.5±0.5; p<0.001) was the highest in R-ZES and lowest in N-BES. Heterogeneity score was higher in R-ZES than in N-BES (N-BES, 0.8±0.4; X-EES, 0.9±0.4; R-ZES, 1.1±0.5; p=0.007). Maximum yellow color grade and prevalence of thrombus were not different. Multivariate analysis demonstrated that only stent type was associated with maximum neointima coverage grade; stent type and total stent length were associated with heterogeneity score; and stenting for acute coronary syndrome (ACS) and total stent length were associated with maximum yellow color grade.CONCLUSIONS:Neointima coverage and heterogeneity were mainly determined by stent type even among second-generation DES, while yellow color was determined mainly by whether target lesion was of ACS. |
DOI | 10.1016/j.jjcc.2016.11.012 |
PMID | 28034576 |