Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Does Treatment of Impaired Glucose Tolerance Improve Cardiovascular Outcomes in Patients with Previous Myocardial Infarction? |
Journal | Formal name:Cardiovascular drugs and therapy Abbreviation:Cardiovasc Drugs Ther ISSN code:1573-7241(Electronic)0920-3206(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 31(4),pp.401-11 |
Papers・Author | Asakura Masanori, Kim Jiyoong, Asanuma Hiroshi, Hamasaki Toshimitsu, Tsukahara Kengo, Higashino Yorihiko, Ishikawa Tetsuya, Nakama Yasuharu, Koba Shinji, Maruyama Yasuyuki, Tsujimoto Mitsuru, Himeno Hideo, Ohkusa Takanori, Fujino Susumu, Shimizu Makoto, Endo Tsutomu, Yoda Shunichi, Muroya Takahiro, Murohara Toyoaki, Ohte Nobuyuki, Suzuki Hiroshi, Kohno Tohru, Fukui Kazuki, Shiono Takaaki, Takase Hiroyuki, Uzui Hiroyasu, Nagai Yoshiyuki, Hashimoto Yuji, Ikeda Shuntaro, Mizuno Sumio, Tamita Koichi, Fujita Masashi, Satake Kazuo, Kinoshita Yoshihiko, Nunohiro Tatsuya, Sakagami Satoru, Higaki Jitsuo, Morii Isao, Sawada Reimin, Hiasa Yoshikazu, Shigemasa Tomohiko, Nakahama Makoto, Sata Masataka, Doi Osamu, Ueda Tetsuro, Yamada Takahisa, Yamanouchi Takayoshi, Yamaguchi Hajime, Morita Yukiko, Hayashi Hideki, Kitakaze Masafumi |
Publication date | 2017/08 |
Papers・Description | PURPOSE:We evaluated the effects of an alpha-glucosidase inhibitor, voglibose, on cardiovascular events in patients with a previous myocardial infarction (MI) and impaired glucose tolerance (IGT).METHODS:This prospective, randomized, open, blinded-endpoint study was conducted in 112 hospitals and clinics in Japan in 3000 subjects with both previous MI and IGT receiving voglibose (0.6 mg/day, n = 424) or no drugs (n = 435) for 2 years. The Data and Safety Monitoring Board (DSMB) recommended discontinuation of the study in June 2012 afteran interim analysis when the outcomes of 859 subjects were obtained. The primary endpoint was cardiovascular events including cardiovascular death, nonfatal MI, nonfatal unstable angina, nonfatal stroke, and percutaneous coronary intervention/coronary artery bypass graft. Secondary endpoints included individual components of the primary endpoint in addition to all-cause mortality and hospitalization due to heart failure.RESULTS:The age, ratio of males, and HbA1C were 65 vs. 65 years, 86 vs. 87%, and 5.6 vs. 5.5% in the groups with and without voglibose, respectively. Voglibose improved IGT; however, Kaplan-Meier analysis showed no significant between-group difference with respect to cardiovascular events [12.5% with voglibose vs. 10.1% without voglibose for the primary endpoint (95% confidence interval, 0.82-1.86)]; there were no significant differences in secondary endpoints.CONCLUSION:Although voglibose effectively treated IGT, no additional benefits for cardiovascular events in patients with previous MI and IGT were observed. Voglibose may not be a contributing therapy to the secondary prevention in patients with MI and IGT.TRIAL REGISTRATION:Clinicaltrials.gov number: NCT00212017. |
DOI | 10.1007/s10557-017-6740-3 |
PMID | 28779371 |