Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Not refereed |
Title | Impact of Preferentially Expressed Antigen of Melanoma on the Prognosis of Hepatocellular Carcinoma |
Journal | Formal name:Gastrointestinal tumors Abbreviation:Gastrointest Tumors ISSN code:2296-3774(Print)2296-3774(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 3(3-4),pp.128-35 |
Papers・Author | Oyama Kenji, Kanki Keita, Shimizu Hiroki, Kono Yohei, Azumi Junya, Toriguchi Kan, Hatano Etsuro, Shiota Goshi |
Publication date | 2017/03 |
Papers・Description | BACKGROUND:Retinoids, vitamin A and its derivatives, have an antitumor effect on hepatocellular carcinoma (HCC). The function of retinoids is exerted by the complex of retinoic acid (RA) with the heterodimer of retinoid X receptor and the RA receptor. The preferentially expressed antigen of melanoma (PRAME) acts as a dominant repressor of RA signaling by binding to the complex. The significance of PRAME on the prognosis of HCC remains to be clarified.METHODS:PRAME mRNA expression was examined by quantitative real-time polymerase chain reaction in both tumor and non-tumor tissues of 100 HCC patients who received surgical resection. The effect of PRAME knockdown on DR5-mediated RA transcriptional activity was examined.RESULTS:In tumor tissues, there were significant associations among PRAME expression, clinical stage, tumor markers, and tumor numbers. In non-tumor tissues, there were significant associations among PRAME expression, overall survival, and disease-free survival. The knockdown of PRAME caused no reduction in DR5-mediated transcriptional activity of RA, suggesting that PRAME acts via other mechanisms than the DR5 RA-responsive elements.CONCLUSION:Our findings indicate that PRAME expression is a novel prognostic marker in HCC patients. |
DOI | 10.1159/000448137 |
PMID | 28611979 |