Faculty Information |
|
Article types | Introduction |
Language | English |
Refereed paper | Refereed |
Title | Novel Regenerative Therapies Based on Regionally Induced Multipotent Stem Cells in Post-Stroke Brains: Their Origin, Characterization, and Perspective. |
Journal | Formal name:Translational stroke research Abbreviation:Transl Stroke Res ISSN code:1868-601X(Electronic)1868-4483(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 8(6),pp.515-528 |
Papers・Author | Takagi Toshinori, Yoshimura Shinichi, Sakuma Rika, Nakano-Doi Akiko, Matsuyama Tomohiro, Nakagomi Takayuki |
Publication date | 2017/12 |
Papers・Description | Brain injuries such as ischemic stroke cause severe neural loss. Until recently, it was believed that post-ischemic areas mainly contain necrotic tissue and inflammatory cells. However, using a mouse model of cerebral infarction, we demonstrated that stem cells develop within ischemic areas. Ischemia-induced stem cells can function as neural progenitors; thus, we initially named them injury/ischemia-induced neural stem/progenitor cells (iNSPCs). However, because they differentiate into more than neural lineages, we now refer to them as ischemia-induced multipotent stem cells (iSCs). Very recently, we showed that putative iNSPCs/iSCs are present within post-stroke areas in human brains. Because iNSPCs/iSCs isolated from mouse and human ischemic tissues can differentiate into neuronal lineages in vitro, it is possible that a clearer understanding of iNSPC/iSC profiles and the molecules that regulate iNSPC/iSC fate (e.g., proliferation, differentiation, and survival) would make it possible to perform neural regeneration/repair in patients following stroke. In this article, we introduce the origin and traits of iNSPCs/iSCs based on our reports and recent viewpoints. We also discuss their possible contribution to neurogenesis through endogenous and exogenous iNSPC/iSC therapies following ischemic stroke. |
DOI | 10.1007/s12975-017-0556-0 |
PMID | 28744717 |