Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Pericyte-derived Bone Morphogenetic Protein 4 Underlies White Matter Damage after Chronic Hypoperfusion. |
Journal | Formal name:Brain pathology (Zurich, Switzerland) Abbreviation:Brain Pathol ISSN code:1750-3639(Electronic)1015-6305(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 28,pp.521-535 |
Papers・Author | Uemura Maiko T, Ihara Masafumi, Maki Takakuni, Nakagomi Takayuki, Kaji Seiji, Uemura Kengo, Matsuyama Tomohiro, Kalaria Raj N, Kinoshita Ayae, Takahashi Ryosuke |
Publication date | 2018/05 |
Papers・Description | Subcortical small vessel disease (SVD) is characterized by white matter damage resulting from arteriolosclerosis and chronic hypoperfusion. Transforming growth factor beta 1 (TGFB1) is dysregulated in the hereditary SVD, CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy). However, very little is known about the role of the largest group in the TGFB superfamily - the bone morphogenetic proteins (BMPs) - in SVD pathogenesis. The aim of this study was to characterize signaling abnormalities of BMPs in sporadic SVD. We examined immunostaining of TGFB1 and BMPs (BMP2/BMP4/BMP6/BMP7/BMP9) in a total of 19 post-mortem human brain samples as follows: 7 SVD patients (4 males, 76-90 years old); 6 Alzheimer's disease (AD) patients (2 males, 67-93 years old); and 6 age-matched disease controls (3 males, 68-78 years old). We subsequently investigated the effects of oxygen-glucose deprivation and BMP4 addition on cultured cells. |
DOI | 10.1111/bpa.12523 |
PMID | 28470822 |