教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Pericyte-derived Bone Morphogenetic Protein 4 Underlies White Matter Damage after Chronic Hypoperfusion. |
掲載誌名 | 正式名:Brain pathology (Zurich, Switzerland) 略 称:Brain Pathol ISSNコード:1750-3639(Electronic)1015-6305(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 28,pp.521-535 |
著者・共著者 | Uemura Maiko T, Ihara Masafumi, Maki Takakuni, Nakagomi Takayuki, Kaji Seiji, Uemura Kengo, Matsuyama Tomohiro, Kalaria Raj N, Kinoshita Ayae, Takahashi Ryosuke |
発行年月 | 2018/05 |
概要 | Subcortical small vessel disease (SVD) is characterized by white matter damage resulting from arteriolosclerosis and chronic hypoperfusion. Transforming growth factor beta 1 (TGFB1) is dysregulated in the hereditary SVD, CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy). However, very little is known about the role of the largest group in the TGFB superfamily - the bone morphogenetic proteins (BMPs) - in SVD pathogenesis. The aim of this study was to characterize signaling abnormalities of BMPs in sporadic SVD. We examined immunostaining of TGFB1 and BMPs (BMP2/BMP4/BMP6/BMP7/BMP9) in a total of 19 post-mortem human brain samples as follows: 7 SVD patients (4 males, 76-90 years old); 6 Alzheimer's disease (AD) patients (2 males, 67-93 years old); and 6 age-matched disease controls (3 males, 68-78 years old). We subsequently investigated the effects of oxygen-glucose deprivation and BMP4 addition on cultured cells. |
DOI | 10.1111/bpa.12523 |
PMID | 28470822 |