Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | The Impact of Transforming Growth Factor-β1 Level on Outcome After Catheter Ablation in Patients With Atrial Fibrillation. |
Journal | Formal name:Journal of cardiovascular electrophysiology Abbreviation:J Cardiovasc Electrophysiol ISSN code:1540-8167(Electronic)1045-3873(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 28(4),pp.402-9 |
Papers・Author | Kishima Hideyuki, Mine Takanao, Takahashi Satoshi, Ashida Kenki, Ishihara Masaharu, Masuyama Tohru |
Publication date | 2017/04 |
Papers・Description | INTRODUCTION:Transforming growth factor-β1 (TGF-β1 ) is an important factor that induces atrial fibrosis and atrial fibrillation (AF). The purpose of this study was to evaluate the association between TGF-β1 level and clinical factors before catheter ablation (CA), and to investigate the impact of TGF-β1 level on the outcome after CA for AF.METHODS AND RESULTS:This prospective studyincluded 151 patients (persistent AF group: n = 59, paroxysmal AF [PAF]group: n = 54, and control group: n = 38). All patients who underwent CA for AF were followed up for 12 months. The PAF group had the highest TGF-β1 levels in all patients. An early recurrence of AF (ERAF: defined as episodes of atrial tachyarrhythmia within a 3-month blanking period) was detected in 60 patients (53%). Recurrent AF after the blanking period was detected in 36 patients (32%). On multivariate analysis, low TGF-β1 level was the only independent factor associated with recurrent AF. Moreover, the AF recurrence ratio was higher in the low TGF-β1 group (<12.56 ng/mL) than in the high TGF-β1 group (16 of 29 patients, 55% vs. 20 of 84 patients, 24%, P = 0.002 by log-rank test).CONCLUSIONS:PAF was associated with a higher TGF-β1 level. Moreover, lower TGF-β1 level in AF patients could be a cause of recurrent AF after CA. |
DOI | 10.1111/jce.13169 |
PMID | 28127812 |