Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Evaluation of influenza vaccine-immunogenicity in cell-mediated immunity. |
Journal | Formal name:Cellular immunology Abbreviation:Cell Immunol ISSN code:1090-2163(Electronic)0008-8749(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 310,pp.165-9 |
Papers・Author | Otani Naruhito, Shima Masayuki, Ueda Takashi, Ichiki Kaoru, Nakajima Kazuhiko, Takesue Yoshio, Okuno Toshiomi |
Publication date | 2016/12 |
Papers・Description | The immunological effect of influenza vaccines cannot be evaluated accurately using an antibody titer. Therefore, we used a new method that measures cell-mediated immunity to investigate changes in the amount of interferon-gamma (IFN-γ) produced after vaccination in response to the vaccine antigen. The study was conducted during the 2014-2015 influenza season in 23 adults, using a vaccine that contained three types of antigen. The IFN-γ level increased by at least 1.5 times in 65% (15/23) of cases in response tothe H1N1 antigen, in 57% (13/23) of cases in response to the H3N2 antigen, and in 57% (13/23) of cases in response to the B antigen. During the study period, 4 subjects developed type A influenza. Our data showed that the IFN-γ level did not increase by 1.5 times in these subjects. We propose that the efficacy of influenza vaccines may be evaluated by measuring changes in the level of IFN-γ produced in response to influenza vaccine. |
DOI | 10.1016/j.cellimm.2016.09.005 |
PMID | 27665371 |