教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Evaluation of influenza vaccine-immunogenicity in cell-mediated immunity. |
掲載誌名 | 正式名:Cellular immunology 略 称:Cell Immunol ISSNコード:1090-2163(Electronic)0008-8749(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 310,pp.165-9 |
著者・共著者 | Otani Naruhito, Shima Masayuki, Ueda Takashi, Ichiki Kaoru, Nakajima Kazuhiko, Takesue Yoshio, Okuno Toshiomi |
発行年月 | 2016/12 |
概要 | The immunological effect of influenza vaccines cannot be evaluated accurately using an antibody titer. Therefore, we used a new method that measures cell-mediated immunity to investigate changes in the amount of interferon-gamma (IFN-γ) produced after vaccination in response to the vaccine antigen. The study was conducted during the 2014-2015 influenza season in 23 adults, using a vaccine that contained three types of antigen. The IFN-γ level increased by at least 1.5 times in 65% (15/23) of cases in response tothe H1N1 antigen, in 57% (13/23) of cases in response to the H3N2 antigen, and in 57% (13/23) of cases in response to the B antigen. During the study period, 4 subjects developed type A influenza. Our data showed that the IFN-γ level did not increase by 1.5 times in these subjects. We propose that the efficacy of influenza vaccines may be evaluated by measuring changes in the level of IFN-γ produced in response to influenza vaccine. |
DOI | 10.1016/j.cellimm.2016.09.005 |
PMID | 27665371 |