教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Serum Macro TSH Level is Associated with Sleep Quality in Patients with Cardiovascular Risks: HSCAA study |
掲載誌名 | 正式名:Scientific Reports ISSNコード:2045-2322 |
掲載区分 | 国外 |
出版社 | SPRINGER NATURE |
巻・号・頁 | pp.online |
著者・共著者 | Manabu Kadoya, Sachie Koyama, Akiko Morimoto, Akio Miyoshi, Miki Kakutani, Kae Hamamoto, Masafumi Kurajoh, Takuhito Shoji, Yuji Moriwaki, Masahiro Koshiba, Tetsuya Yamamoto, Masaaki Inaba, Mitsuyoshi Namba & Hidenori Koyama
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発行年月 | 2017/03 |
概要 | Macro thyroid-stimulating hormone (TSH) has been reported to be associated with seasonality and regulated by changes in day length in rodents, different from free TSH. In the present study, we investigated structural differences between macro TSH and free TSH levels in human serum, as well as the association of macro TSH with sleep quality. We enrolled 314 patients registered in the Hyogo Sleep Cardio-Autonomic Atherosclerosis (HSCAA) study. Sleep quality shown by actigraphy, sleep physical activity, and percent sleep in all and TSH closely matched subjects were significantly associated with high macro TSH levels. Macro and free TSH were similarly increased following thyrotropin-releasing hormone (TRH) stimulation, while circadian changes associated with those were distinct. To further analyze the structure of macro TSH, serum samples were separated by gel filtration chromatography. Although treatment with glycosidase did not affect morbidity, the macro TSH fraction had a markedly low affinity to the Con A column as compared with free TSH, indicating a distinct glycosylation structure. In conclusion, an increase in serum macro TSH is associated with low sleep quality and regulated in a manner distinct from free TSH, potentially due to an altered glycosylation structure. |
DOI | 10.1038/srep44387 |