教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | A Multicenter Feasibility Study of EBUS-TBNA for Potentially Operable Non-Small Cell Lung Cancer: The JMTO LC07-02 Study (UMIN000001280). |
掲載誌名 | 正式名:Oncology research and treatment 略 称:Oncol Res Treat ISSNコード:2296-5262(Electronic)2296-5270(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 39(10),pp.629-633 |
著者・共著者 | Tanaka Fumihiro, Hasegawa Seiki, Kondo Nobuyuki, Miyahara Ryo, Date Hiroshi, Atagi Shinji, Kawahara Masaaki, Yamanaka Takeharu, Manabe Toshiaki, Wada Hiromi |
発行年月 | 2016 |
概要 | BACKGROUND:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a standard procedure for the pathological evaluation of the mediastinal nodal (N2) status of lung cancer; however, its feasibility in potentially operable patients with suspicion of minimal N2 disease remains unestablished.PATIENTS AND METHODS:A prospective multicenter study was conducted to assess the feasibility of EBUS-TBNA in this setting. Patients with clinical stage IIIA-N2 non-small cell lung cancer (NSCLC) and mediastinalnodal enlargement on computed tomography (CT) were eligible; patients were ineligible when CT revealed bulky (>3 cm in the long-axis diameter) N2 or multiple (≥ 3) station N2. If EBUS-TBNA revealed negative results, surgical staging procedures were mandatory.RESULTS:Among 20 eligible patients, EBUS-TBNA provided pathological confirmation of N2 disease (true-positive) in 12 patients. Among 8 patients with negative results with EBUS-TBNA, 4 patients were pathologically diagnosed as having N2 disease with surgical staging procedures (false-negative), and 4 were finally diagnosed as having non-N2 disease with nodal dissection by thoracotomy (true-negative). As a result, the sensitivity of EBUS-TBNA for N2 evaluation (primary endpoint) was 75.0% (95% confidence interval 47.6-92.7%). No grade 3-5 adverse event were documented.CONCLUSION:EBUS-TBNA is potentially safe and useful in the pathological evaluation of N2 status even in potentially operable NSCLC patients with suspicion of minimal N2 disease on preoperative CT. |
DOI | 10.1159/000447989 |
PMID | 27710975 |