Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation. |
Journal | Formal name:Surgery Abbreviation:Surgery ISSN code:1532-7361(Electronic)0039-6060(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 158(2),pp.399-407 |
Papers・Author | Kohama Keisuke, Yamashita Hayato, Aoyama-Ishikawa Michiko, Takahashi Toru, Billiar Timothy R, Nishimura Takeshi, Kotani Joji, Nakao Atsunori |
Publication date | 2015/08 |
Papers・Description | INTRODUCTION:Hemorrhagic shock followed by fluid resuscitation (HS/R) triggers an inflammatory response and causes pulmonary inflammation that can lead to acute lung injury (ALI). Hydrogen, a therapeutic gas, has potent cytoprotective, antiinflammatory, and antioxidant effects. This study examined the effects of inhaled hydrogen on ALI caused by HS/R.METHODS:Rats were subjected to hemorrhagic shock by withdrawing blood to lower blood pressure followed by resuscitation with shed blood and saline to restore blood pressure. After HS/R, the rats were maintained in a control gas of similar composition to room air or exposed to 1.3% hydrogen.RESULTS:HS/R induced ALI, as demonstrated by significantly impaired gas exchange, congestion, edema, cellular infiltration, and hemorrhage in the lungs. Hydrogen inhalation mitigated lung injury after HS/R, as indicated by significantly improved gas exchange and reduced cellular infiltration and hemorrhage. Hydrogen inhalation did not affect hemodynamic status during HS/R. Exposure to 1.3% hydrogen significantly attenuated the upregulation of the messenger RNAs for several proinflammatory mediators induced by HS/R. Lipid peroxidation was reduced significantly in the presence of hydrogen, indicating antioxidant effects.CONCLUSION:Hydrogen, administered through inhalation, may exert potent therapeutic effects against ALI induced by HS/R and attenuate the activation of inflammatory cascades. |
DOI | 10.1016/j.surg.2015.03.038 |
PMID | 25983276 |