Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Immunosuppression Modification by Everolimus With Minimization of Calcineurin Inhibitors Recovers Kidney Graft Function Even in Patients With Very Late Conversion and Also With Poor Graft Function. |
Journal | Formal name:Transplantation proceedings Abbreviation:Transplant Proc ISSN code:1873-2623(Electronic)0041-1345(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 49(1),pp.41-4 |
Papers・Author | Nojima Michio, Yamada Yusuke, Higuchi Yoshihide, Shimatani Kimihiro, Kanematsu Akihiro, Yamamoto Shingo |
Publication date | 2017/01 |
Papers・Description | BACKGROUND:Although kidney graft survival within 5 years after transplantation is now achieved in>95% of recipients, chronic graft deterioration remains a factor limiting long-term survival. Chronic nephrotoxicity induced by calcineurin inhibitors (CNIs) is one of the major causes of chronic graft injury; thus, minimization of CNIs by administration of everolimus (EVR) isexpected to relieve their toxic effects.METHODS:Fifty-six kidney transplant recipients receiving CNI-based immunosuppression (tacrolimus, n = 34; cyclosporine, n = 22) were analyzed. The average posttransplant period at conversion was 7.4 years and no less than 3 years. Conversion of immunosuppression was accomplished by reducing CNI by 40% in dose and beginning EVR at 1 or 1.5 mg. |
DOI | 10.1016/j.transproceed.2016.11.018 |
PMID | 28104155 |