教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Enhancement of death receptor 4-mediated apoptosis and cytotoxicity in renal cell carcinoma cells by anisomycin. |
掲載誌名 | 正式名:Anti-cancer drugs 略 称:Anticancer Drugs ISSNコード:1473-5741(Electronic)0959-4973(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 28(2),pp.180-6 |
著者・共著者 | Li Yongnan, Wu Xiuxian, Jin Xinghua, Wang Jiumei, Togo Yoshikazu, Suzuki Toru, Hashimoto Takahiko, Yamada Yusuke, Nakanishi Yukako, Kanematsu Akihiro, Nojima Michio, Kakehi Yoshiyuki, Yamamoto Shingo |
発行年月 | 2017/02 |
概要 | UNASSIGNED:Renal cell carcinoma (RCC) is one of the most drug-resistant malignancies, and an effective therapy is lacking for metastatic RCC. Anisomycin is known to inhibit protein synthesis and induce ribotoxic stress. The aim of this study was to explore whether anisomycin enhances the cytotoxic effects of mapatumumab, a human agonistic monoclonal antibody specific for death receptor 4 (DR4), in human RCC cells. We examined the cytotoxicity of anisomycin alone and in combination with mapatumumab in human RCC cell lines and primary RCC cell cultures. RCC cells treated with anisomycin showed cytotoxicity in a dose-dependent manner. |
DOI | 10.1097/CAD.0000000000000450 |
PMID | 27879498 |