Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Impact of Donor-Specific Antibodies on Graft Fibrosis After Pediatric Living Donor Liver Transplantation for Biliary Atresia |
Journal | Formal name:Transplantation proceedings Abbreviation:Transplant Proc ISSN code:1873-2623(Electronic)0041-1345(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 48(4),pp.1095-9 |
Papers・Author | Ueno T, Zenitani M, Yamanaka H, Tanaka N, Uehara S, Tazuke Y, Bessho K, Okuyama H |
Publication date | 2016/05 |
Papers・Description | BACKGROUND:Pediatric living donor liver transplant (LDLT) patients sometimes develop graft fibrosis after non-recurrent diseases such as biliary atresia (BA). Donor-specific antibodies (DSA) have recently been shown to play a possible role in graft damage after liver transplantation. We report the impact of DSA on pediatric LDLT for BA patients.METHODS:Patients under age 18 years who received LDLT for BA at our institution and who had at least 5 years' follow-up were identified, and 23 were eventually enrolled in this study. Pathological findings were assessed with the use of the last available biopsy. Patients were divided into 2 groups, DSA-positive and DSA-negative. GraftMETHODS:fibrosis after LDLT was assessed according to DSA groups.RESULTS:The mean patient age at transplant was 2.6 years. The mean time to the last available biopsy after LDLT was 8.2 years (4.8-15.6 years); 6 patients (26%) showed no fibrosis, whereas fibrosis was graded as F1, F2, or F3 in 8 patients (35%), 8 patients (35%), and 1 patient, respectively. DSA were observed in 12 patients (52%). Moderate graft fibrosis (F2 and F3) was found in 7 (58%) of the DSA-positive group, but only 2 (18%) of the DSA-negative group, showing a statistically significant difference (P RESULTS:<RESULTS:.05). Pre-transplant cross-matching was performed in 17 patients. The 2 patients with a positive cross-match were DSA-positive. Six cross-match-negative patients developed de novo DSA after LDLT.CONCLUSIONS:Graft fibrosis was observed after LDLT for BA during long-term follow-up, more commonly in DSA-positive patients. DSA may play a role in fibrosis formation. |
DOI | 10.1016/j.transproceed.2016.02.011 |
PMID | 27320565 |