教員業績データベース |
|
論文種別 | 症例報告 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Histological features of mixed neuroendocrine carcinoma and hepatocellular carcinoma in the liver: a case report and literature review |
掲載誌名 | 正式名:Clinical journal of gastroenterology 略 称:Clin J Gastroenterol ISSNコード:1865-7265(Electronic)1865-7265(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 9(4),pp.272-9 |
著者・共著者 | Nishino Hiroto, Hatano Etsuro, Seo Satoru, Shibuya Shinsuke, Anazawa Takayuki, Iida Taku, Masui Toshihiko, Taura Kojiro, Haga Hironori, Uemoto Shinji |
発行年月 | 2016/08 |
概要 | Primary hepatic neuroendocrine carcinoma (NEC) is rare, and its origin, clinical features, diagnosis and treatment have not been clarified. Primary mixed NEC and hepatocellular carcinoma (HCC) is even rarer and is divided into either combined type or collision type. We report a patient with the combined type of mixed NEC and HCC. A 72-year-old male was diagnosed with HCC and underwent hepatectomy because of the presence of two tumors in his liver. Histological examination demonstrated that one of the tumors had both NEC and HCC components. The transitional zone was noted in the immunohistological examination, and the tumor was determined to be the combined type of primary mixed NEC and HCC. This was the first description of an HCC component being found in an NEC-dominant area in a primary mixed NEC and HCC tumor. Three weeks after hepatectomy, an abdominal computed tomography scan showed extensive regional and para-aortic lymphadenopathy, and early relapse was suspected in the patient. The patient died 3 months after the operation despite treatment with combination chemotherapy. This report describes an unfavorable case and summarizes all the primary mixed NEC and HCC tumor cases that have been previously reported. |
DOI | 10.1007/s12328-016-0669-0 |
PMID | 27384317 |