Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Not refereed |
Title | Feasibility of the liver-first approach for patients with initially unresectable and not optimally resectable synchronous colorectal liver metastases |
Journal | Formal name:Surgery today Abbreviation:Surg Today ISSN code:1436-2813(Electronic)0941-1291(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 46(6),pp.721-8 |
Papers・Author | Okuno Masayuki, Hatano Etsuro, Kasai Yosuke, Nishio Takahiro, Seo Satoru, Taura Kojiro, Yasuchika Kentaro, Nitta Takashi, Mori Akira, Okajima Hideaki, Kaido Toshimi, Hasegawa Suguru, Matsumoto Shigemi, Sakai Yoshiharu, Uemoto Shinji |
Publication date | 2016/06 |
Papers・Description | PURPOSE:To investigate the outcomes of patients with colorectal cancer and initially unresectable or not optimally resectable liver metastases, who were treated using the liver-first approach in the era of modern chemotherapy in Japan.METHODS:We analyzed and compared data retrospectively on patients with asymptomatic resectable colorectal cancer and initially unresectable or not optimallMETHODS:y resectable liver metastases, who were treated either using the liver-first approach (n = 12, LF group) or the primary-first approach (n = 13, PF group).RESULTS:Both groups of patients completed their therapeutic plan and there was no mortality. Postoperative morbidity rates after primary resection and hepatectomy, and post-hepatectomy liver failure rate were comparable between the groups (p = 1.00, p = 0.91, and p = 0.55, respectively). Recurrence rates, median recurrence-free survival since the last operation, and 3-year overall survival rates from diagnosis were also comparable between the LF and PF groups (58.3 vs. 61.5 %, p = 0.87; 10.5 vs. 18.6 months, p = 0.57; and 87.5 vs. 82.5 %, p = 0.46, respectively).CONCLUSIONS:The liver-first approach may be an appropriate treatment sequence without adversely affecting perioperative or survival outcomes for selected patients. |
DOI | 10.1007/s00595-015-1242-z |
PMID | 26315324 |