Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Not refereed |
Title | Resectability and tumor response after preoperative chemotherapy in hepatoblastoma treated by the Japanese Study Group for Pediatric Liver Tumor (JPLT)-2 protocol |
Journal | Formal name:Journal of pediatric surgery Abbreviation:J Pediatr Surg ISSN code:1531-5037(Electronic)0022-3468(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 51(12),pp.2053-7 |
Papers・Author | Hiyama Eiso, Hishiki Tomoko, Watanabe Kenichiro, Ida Kohmei, Yano Michihiro, Oue Takaharu, Iehara Tomoko, Hoshino Ken, Koh Katsuyoshi, Tanaka Yukichi, Kurihara Sho, Ueda Yuka, Onitake Yoshiyuki |
Publication date | 2016/12 |
Papers・Description | BACKGROUND/PURPOSE:We aimed to clarify whether surgical resectability and tumor response after preoperative chemotherapy (preCTx) represented prognostic factors for patients with hepatoblastoma (HBL) in the JPLT-2 study (1999-2012).METHODS:Patients (N=342) with HBL who underwent preCTx were eligible. PRETEXT, CHIC risk stratification (standard [SRMETHODS:]METHODS:, intermediate [IRMETHODS:]METHODS:and high risk [HRMETHODS:]METHODS:) aMETHODS:t diagnosis, POST-TEXT, and tumor resectability were evaluated by imaging. Tumor response was classified into responders (CR or PR) and nonresponders (NC or PD) according to RECIST criteria.RESULTS:There were 7 PRETEXT I, 106 II, 143 III, and 86 IV, including 71 metastatic HBLs. In POST-TEXT, 12 PRETEXT II, 42 III, and 58 IV were down-staged. The 5-year EFS/OS rates of 198 SR, 73 IR, and 71 HR-HBLs were 82/94%, 49/64%, and 28/34%, respectively. In 198 SR, 154 of 160 responders and 24 of 38 nonresponders survived event-free (PRESULTS:<RESULTS:0.01). In 73 IR, 12 of 24 whose tumors remained unresectable experienced recurrence, 9 of whom were nonresponders (PRESULTS:<RESULTS:0.01). In 71 HR, chemoresponders and tumor resectability after preCTx correlated with favorable outcomes (PRESULTS:<RESULTS:0.05).CONCLUSIONS:Evaluation of response and tumor resectability after preCTx is useful for predicting prognosis in HBLs. To improve outcomes, we should reconsider surgical procedures according to resectability and chemoresponsiveness.LEVEL OF EVIDENCE:Level II. |
DOI | 10.1016/j.jpedsurg.2016.09.038 |
PMID | 27712887 |