教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Plasma leptin concentration is associated with fatigue severity in patients with cardiovascular risk factors - HSCAA study. |
掲載誌名 | 正式名:Psychoneuroendocrinology 略 称:Psychoneuroendocrinology ISSNコード:03064530 |
掲載区分 | 国外 |
巻・号・頁 | 74,pp.7-12 |
著者・共著者 | Kurajoh Masafumi, Kadoya Manabu, Morimoto Akiko, Naka Mariko, Miyoshi Akio, Kanzaki A, Kakutani-Hatayama Miki, Hamamoto K, Shoji Takuhito, Moriwaki Yuji, Yamamoto Tetsuya, Inaba Masafumi, Namba Mitsuyoshi, Koyama Hidenori |
発行年月 | 2016/08 |
概要 | Fatigue induced by complex dysfunctions of the central nervous system is frequently complained by patients with cardiovascular risk factors. Although leptin is considered to regulate the central nervous system, there are no reports regarding its association with fatigue in those patients. This cross-sectional study included 347 patients with cardiovascular risk factors. Fatigue score and plasma leptin concentration were measured. In addition, abdominal fat accumulation, systemic inflammation, sleep condition, and functions of hypothalamus-pituitary axis and autonomic system were estimated. Plasma leptin concentration (natural logarithm transformed) was significantly and positively (r=0.222, p<0.001) associated with fatigue score, and significantly (p<0.001) higher in the moderately-fatigued group (2.32±0.75ng/ml, mean±SD, n=52) than in the normally-fatigued group (1.85±1.02ng/ml, mean±SD, n=295). Multiple logistic regression analysis showed that plasma leptin concentration was significantly and independently associated with a moderately-fatigued condition independent of other factors, including age, gender, presence of diabetes, hypertension, dyslipidemia, alcohol consumption habit, urinary free cortisol, serum high-sensitive CRP concentration, visceral and subcutaneous fat area, apnea/hypopnea index, sleep efficiency, and heart rate variability. Hyperleptinemia may contribute to fatigue severity in patients with cardiovascular risk factors. |
DOI | 10.1016/j.psyneuen.2016.08.016 |
PMID | 27567116 |