Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Not refereed |
Title | Pregnancy outcome in women with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy: a multicenter study from Japan. |
Journal | Formal name:Intestinal research Abbreviation:Intest Res ISSN code:1598-9100(Print)1598-9100(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 14(2),pp.139-45 |
Papers・Author | Komoto Shunsuke, Motoya Satoshi, Nishiwaki Yuji, Matsui Toshiyuki, Kunisaki Reiko, Matsuoka Katsuyoshi, Yoshimura Naoki, Kagaya Takashi, Naganuma Makoto, Hida Nobuyuki, Watanabe Mamoru, Hibi Toshifumi, Suzuki Yasuo, Miura Soichiro, Hokari Ryota |
Publication date | 2016/04 |
Papers・Description | BACKGROUND/AIMS:Anti-tumor necrosis factor drugs (anti-TNF) and thiopurines are important treatment options in patients with inflammatory bowel disease (IBD), including during pregnancy. However, there are limited data on the benefit/risk profile of anti-TNF and thiopurines during pregnancy in Asia. The aim of this study was to analyze pregnancy outcomes of feBACKGROUND/AIMS:male Japanese IBD patients treated with anti-TNF and/or thiopurines.METHODS:This cross-sectional study assessed pregnancy outcomes in 72 women with IBD. Pregnancy outcomes were compared among 31 pregnancies without exposure to infliximab (IFX), adalimumab (ADA), or thiopurines; 24 pregnancies with exposure to anti-TNF treatment (23 IFX, 1 ADA); 7 pregnancies with exposure to thiopurines alone; and 10 pregnancies with exposure to both IFX and thiopurines.RESULTS:Thirty-five of the 41 pregnancies (85.3%) that were exposed to anti-TNF treatment and/or thiopurines resulted in live births after a median gestational period of 38 weeks. Of the 35 live births, 3 involved premature deliveries; 7, low birth weight; and 1, a congenital abnormality. There were 6 spontaneous abortions in pregnancies that were exposed to anti-TNF treatment (17.7%). Pregnancy outcomes among the 4 groups were similar, except for the rate of spontaneous abortions (P =0.037).CONCLUSIONS:Exposure to anti-TNF treatment or thiopurines during pregnancy was not related to a higher incidence of adverse pregnancy outcomes in Japanese IBD patients except for spontaneous abortion. |
DOI | 10.5217/ir.2016.14.2.139 |
PMID | 27175114 |