Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinoma. |
Journal | Formal name:International journal of oncology Abbreviation:Int J Oncol ISSN code:1791-2423(Electronic)1019-6439(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 48(4),pp.1571-80 |
Papers・Author | Togo Yoshikazu, Yoshikawa Yoshie, Suzuki Toru, Nakano Yoshiro, Kanematsu Akihiro, Zozumi Masataka, Nojima Michio, Hirota Seiichi, Yamamoto Shingo, Hashimoto-Tamaoki Tomoko |
Publication date | 2016/04 |
Papers・Description | Somatic mutations of the BRCA1 associated protein-1 (BAP1) gene, which maps to 3p21, have been found in several tumors including malignant mesothelioma, uveal melanoma, and renal cell carcinoma (RCC). The role of BAP1 inactivation in tumor development remains unclear. It has been reported that Vhl knock-out mice did not develop RCC, but Vhl knock-out mice with single allele loss of Bap1 in nephron progenitor cells developed RCC, indicating that Bap1 inactivation may be essential in murine renal tumorigenesis. |
DOI | 10.3892/ijo.2016.3395 |
PMID | 26891804 |