教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinoma. |
掲載誌名 | 正式名:International journal of oncology 略 称:Int J Oncol ISSNコード:1791-2423(Electronic)1019-6439(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 48(4),pp.1571-80 |
著者・共著者 | Togo Yoshikazu, Yoshikawa Yoshie, Suzuki Toru, Nakano Yoshiro, Kanematsu Akihiro, Zozumi Masataka, Nojima Michio, Hirota Seiichi, Yamamoto Shingo, Hashimoto-Tamaoki Tomoko |
発行年月 | 2016/04 |
概要 | Somatic mutations of the BRCA1 associated protein-1 (BAP1) gene, which maps to 3p21, have been found in several tumors including malignant mesothelioma, uveal melanoma, and renal cell carcinoma (RCC). The role of BAP1 inactivation in tumor development remains unclear. It has been reported that Vhl knock-out mice did not develop RCC, but Vhl knock-out mice with single allele loss of Bap1 in nephron progenitor cells developed RCC, indicating that Bap1 inactivation may be essential in murine renal tumorigenesis. |
DOI | 10.3892/ijo.2016.3395 |
PMID | 26891804 |