Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Transferrin Receptor 1 in Chronic Hypoxia-Induced Pulmonary Vascular Remodeling. |
Journal | Formal name:American journal of hypertension Abbreviation:Am J Hypertens ISSN code:1941-7225(Electronic)0895-7061(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 29(6),pp.713-8 |
Papers・Author | Naito Yoshiro, Hosokawa Manami, Sawada Hisashi, Oboshi Makiko, Hirotani Shinichi, Iwasaku Toshihiro, Okuhara Yoshitaka, Morisawa Daisuke, Eguchi Akiyo, Nishimura Koichi, Soyama Yuko, Fujii Kenichi, Mano Toshiaki, Ishihara Masaharu, Tsujino Takeshi, Masuyama Tohru |
Publication date | 2016/06 |
Papers・Description | BACKGROUND:Iron is associated with the pathophysiology of several cardiovascular diseases, including pulmonary hypertension (PH). In addition, disrupted pulmonary iron homeostasis has been reported in several chronic lung diseases. Transferrin receptor 1 (TfR1) plays a key role in cellular iron transport. However, the role of TfR1 in the pathophysiology of PH has not been well characterized. In this study, we investigate the role of TfR1 in the development of hypoxia-induced pulmonary vascular remodeling.METHODS:PH was induced by exposing wild-type (WT) mice and TfR1 heteMETHODS:ro knockout mice to hypoxia for 4 weeks and evaluated via assessment of pulmonary vascular remodeling, right ventricular (RV) systolic pressure, and RV hypertrophy. In addition, we assessed the functional role of TfR1 in pulmonary artery smooth muscle cells in vitro.RESULTS:The morphology of pulmonary arteries did not differ between WT mice and TfR1 hetero knockout mice under normoxic conditions. In contrast, TfR1 hetero knockout mice exposed to 4 weeks hypoxia showed attenuated pulmonary vascular remodeling, RV systolic pressure, and RV hypertrophy compared with WT mice. In addition, the depletion of TfR1 by RNA interference attenuated human pulmonary artery smooth muscle cells proliferation induced by platelet-derived growth factor-BB (PDGF-BB) in vitro.CONCLUSIONS:These results suggest that TfR1 plays an important role in the development of hypoxia-induced pulmonary vascular remodeling. |
DOI | 10.1093/ajh/hpv163 |
PMID | 26419445 |