Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Added value of pretreatment (18)F-FDG PET/CT for staging of advanced gastric cancer: Comparison with contrast-enhanced MDCT. |
Journal | Formal name:European journal of radiology Abbreviation:Eur J Radiol ISSN code:1872-7727(Electronic)0720-048X(Linking) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 85(5),pp.989-995 |
Papers・Author | Kawanaka Yusuke, Kitajima Kazuhiro, Fukushima Kazuhito, Mouri Miya, Doi Hiroshi, Oshima Tsutomu, Niwa Hirotaka, Kaibe Nobuaki, Sasako Mitsuru, Tomita Toshihiko, Miwa Hiroto, Hirota Shozo |
Publication date | 2016/05 |
Papers・Description | PURPOSE:To evaluate the added clinical value of pretreatment (18)F-FDG PET/CT compared with conventional contrast-enhanced multidetector-row CT (CECT) alone for staging of advanced gastric cancerMATERIALS AND METHODS:We studied 106 patients with locally advanced gastric cancer who underwent pretreatment CECT and (18)F-FDG PET/CT. Two experienced reviewers assessed the diagnostic performance of both CECT alone and the combination of CECT and (18)F-FDG PET/CT for the primary tumor, regional lymph node metastasis (N) and distant metastasis (M), rating their diagnostic confidence with a 5-point scoring system for each location. The two methods were compared using receiver operating characteristic (ROC) curve analysis for histopathologic findings, imaging, and clinical follow-up as the reference standards.RESULTS:Among the 106 patients, 96 primary tumors (90.6%) were detected by CECT, while 101 (95.3%) were clearly identified by (18)F-FDG PET/CT (p=0.074). Patient-based areas under the ROC curves for CECT alone versus the combination of CECT and (18)F-FDG PET/CT for diagnosis of N stage, peritoneal dissemination, liver metastasis, distant lymph node metastasis, bone metastasis, metastasis at other sites and oRESULTS:verall M stage were 0.787 vs. 0.858 (p=0.13), 0.866 vs. 0.878 (p=0.31), 0.998 vs. 1.0 (p=0.36), 0.744 vs. 0.865 (p=0.049), 0.786 vs. 0.998 (p=0.034), 0.944 vs. 0.984 (p=0.34), and 0.889 vs. 0.912 (p=0.21), respectively. The diagnostic performance of primary tumor detection and NM staging was not influenced by the histologic subtype.CONCLUSION:Adding (18)F-FDG PET/CT to CECT provides better diagnostic accuracy for detection of distant lymph node metastasis and bone metastasis in patients with untreated advanced gastric cancer. |
DOI | 10.1016/j.ejrad.2016.03.003 |
PMID | 27130061 |