教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Stroke and cardiac cell death: Two peas in a pod |
掲載誌名 | 正式名:Clinical neurology and neurosurgery 略 称:Clin Neurol Neurosurg ISSNコード:1872-6968(Electronic)0303-8467(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 142,pp.145-7 |
著者・共著者 | Gonzales-Portillo Chiara, Ishikawa Hiroto, Shinozuka Kazutaka, Tajiri Naoki, Kaneko Yuji, Borlongan Cesar V |
発行年月 | 2016/03 |
概要 | A close pathological link between stroke brain and heart failure may exist. Here, we discuss relevant laboratory and clinical reports demonstrating neural and cardiac myocyte cell death following ischemic stroke. Although various overlapping risk factors exist between cerebrovascular incidents and cardiac incidents, stroke therapy has largely neglected the cardiac pathological consequences. Recent preclinical stroke studies have implicated an indirect cell death pathway, involving toxic molecules, that originates from the stroke brain and produces cardiac cell death. In concert, previous laboratory reports have revealed a reverse cell deathcascade, in that cardiac arrest leads to ischemic cell death in the brain. A deeper understanding of the crosstalk of cell death pathways between stroke and cardiac failure will facilitate the development of novel treatments designed to arrest the global pathology of both diseases thereby improving the clinical outcomes of patients diagnosed with stroke and heart failure. |
DOI | 10.1016/j.clineuro.2016.01.001 |
PMID | 26866777 |