教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Ambient particulate air pollution and circulating antioxidant enzymes: A repeated-measure study in healthy adults in Beijing, China. |
掲載誌名 | 正式名:Environmental pollution (Barking, Essex : 1987) 略 称:Environ Pollut ISSNコード:1873-6424(Electronic)0269-7491(Linking) |
巻・号・頁 | 208(Pt A),pp.16-24 |
著者・共著者 | Wu Shaowei, Wang Bin, Yang Di, Wei Hongying, Li Hongyu, Pan Lu, Huang Jing, Wang Xin, Qin Yu, Zheng Chanjuan, Shima Masayuki, Deng Furong, Guo Xinbiao |
発行年月 | 2016/01 |
概要 | The association of systemic antioxidant activity with ambient air pollution has been unclear. A panel of 40 healthy college students underwent repeated blood collection for 12 occasions under three exposure scenarios before and after relocating from a suburban area to an urban area in Beijing, China in 2010-2011. We measured various air pollutants including fine particles (PM2.5) and determined circulating levels of antioxidant enzymes extracellular superoxide dismutase (EC-SOD) and glutathione peroxidase 1 (GPX1) in the laboratory. An interquartile range increase of 63.4 μg/m(3) at 3-d PM2.5 moving average was associated with a 6.3% (95% CI: 0.6, 12.4) increase in EC-SOD and a 5.5% (95% CI: 1.3, 9.8) increase in GPX1. Several PM2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1. Our results support activation of circulating antioxidant enzymes following exposure to particulate air pollution. |
DOI | 10.1016/j.envpol.2015.06.002 |
PMID | 26074023 |