教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Interleukin-10 and interleukin-5 balance in patients with active asthma, those in remission, and healthy controls. |
掲載誌名 | 正式名:Asia Pacific allergy 略 称:Asia Pac Allergy ISSNコード:2233-8276(Print)2233-8276(Linking) |
巻・号・頁 | 5(4),pp.210-5 |
著者・共著者 | Tomiita Minako, Campos-Alberto Eduardo, Shima Masayuki, Namiki Masanobu, Sugimoto Kazuo, Kojima Hiroyuki, Watanabe Hiroko, Sekine Kunio, Nishimuta Toshiyuki, Kohno Yoichi, Shimojo Naoki |
発行年月 | 2015/10 |
概要 | BACKGROUND:The immunological mechanisms of asthma remission remain unclear although several reports have suggested that balance between T helper (Th) 2 cytokines and regulatory cytokines is related.OBJECTIVE:To study the balance between interleukin (IL) 10 and IL-5 in asthma clinical remission.METHODS:We measured the numbers of IL-5 and IL-10 producing cells in peripheral blood mononuclear cells stimulated with mite antigen obtained from patients with active asthma (group A, n = 18), patients in clinical remission (group R, n = 15) and nonatopic healthy controls (group H, n = 14).RESULTS:The numbers of IL-5 producing cells iRESULTS:n groups A and R were significantly higher than in group H. The number of IL-5 producing cells was lower in group R than in group A, although the difference was not statistically significant. The number of IL-10 producing cells was higher in group R than in group A, although again the difference was not statistically significant. There was a significant difference in the number of IL-10 producing cells between groups A and H but not between groups R and H. The ratio of the number of IL-10 to IL-5 producing cells was highest in group H followed by groups R and A, and the differences were statistically significant for each pair of groups.CONCLUSION:Our study suggests that the IL-10/IL-5 balance is related to clinical asthma. The balance differs between patients in clinical remission and healthy controls, suggesting that allergic inflammation may continue even after clinical asthma remission. |
DOI | 10.5415/apallergy.2015.5.4.210 |
PMID | 26539403 |