Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Association between traffic-related air pollution and asthma in preschool children in a national Japanese nested case-control study. |
Journal | Formal name:BMJ open Abbreviation:BMJ Open ISSN code:2044-6055(Electronic) |
Domestic / Foregin | Foregin |
Volume, Number, Page | 6(2),pp.e010410 |
Papers・Author | Hasunuma Hideki, Sato Tosiya, Iwata Tsutomu, Kohno Yoichi, Nitta Hiroshi, Odajima Hiroshi, Ohara Toshimasa, Omori Takashi, Ono Masaji, Yamazaki Shin, Shima Masayuki |
Publication date | 2016/02 |
Papers・Description | OBJECTIVES:There has been little study on the effect of traffic-related air pollution on the incidence and persistence of asthma in preschool children. We evaluated the association of exposure to traffic-related air pollution with the incidence/persistence of asthma during the first 3 years of life using a population-based study.METHODS:A baseline survey was conducted in 1½-year-old children (n=63 266). A follow-up survey at 3 years of age (n=43 343) identifieMETHODS:d new-onset asthma cases (n=853) and persistence of asthma (n=214). In the prevalence/persistence study, the outdoor concentrations of nitrogen oxides (NOx) and elemental carbon (EC) at home during the first 1½ years of life were estimated by a dispersion model. In the nested case-control study, which regarded incidence of asthma as cases, the personal exposure levels were estimated by dispersion model including time-activity pattern.RESULTS:There was no statistically significant association between the incidence of asthma between age 1½ and 3 years and personal exposure levels to NOx nor EC. However, the persistence of asthmatic symptoms (between 1½ and 3 years) was significantly associated with outdoor concentrations of NOx. ORs for the persistence of asthmatic symptoms were 6.02 (95% CI 1.51 to 23.92) for the comparison between the upper 5th and lower 25th centiles of NOx.CONCLUSIONS:While no statistically significant association was observed for the incidence of asthma, the persistence of asthmatic symptoms in preschool children was significantly associated with traffic-related air pollution. This supports its importance as a risk factor in childhood airway disease. |
DOI | 10.1136/bmjopen-2015-010410 |
PMID | 26916696 |