Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Not refereed |
Title | Early-phase differences in health-related quality of life, psychological status, and physical function between human leucocyte antigen-haploidentical and other allogeneic haematopoietic stem cell transplantation recipients. |
Journal | Formal name:European journal of oncology nursing : the official journal of European Oncology Nursing Society Abbreviation:Eur J Oncol Nurs ISSN code:1532-2122(Electronic)1462-3889(Linking) |
Volume, Number, Page | 19(5),pp.443-50 |
Papers・Author | Morishita Shinichiro, Kaida Katsuji, Yamauchi Shinya, Wakasugi Tatsushi, Ikegame Kazuhiro, Kodama Norihiko, Ogawa Hiroyasu, Domen Kazuhisa |
Publication date | 2015/10 |
Papers・Description | PURPOSE:This study investigated the differences between allogeneic haematopoietic stem cell transplantation (allo-HSCT) patients receiving HSC from human leucocyte antigen (HLA)-haploidentical donors (HID) and other donors that included HLA-matched sibling, matched unrelated, and unrelated umbilical cord blood donors in the 6 weeks after HSCT with respect to quality of life (QOL), psychological status, and physical function.METHODS:The study included 126 patients (HID group, n = 100; other donor group, n = 26) who underwent allo-HSCT between July 2007 and December 2012. Patients were evaluated for health-related QOL using the Medical Outcome Study 36-item Short Form Health Survey. Psychological status was measured by Hospital Anxiety and Depression Scale. Physical function was assessed using tests for handgrip strength, knee extensor strength, and the 6-min walk test.RESULTS:After HSCT, the HID group showed significantly greater improvements in the general health subscale and Mental Component Summary (MCS) of QOL than the other donor group (P RESULTS:<RESULTS: 0.01). Multivariate analysis confirmed that complete remission and age were associated with changes in the general health subscale before and after HSCT (P RESULTS:<RESULTS: 0.05). WithRESULTS:regard to physical function, the HID group showed significantly more decline than the other donor group with respect to handgrip strength and knee extensor muscle strength after HSCT (P RESULTS:<RESULTS: 0.05). Total corticosteroid dose was associated with decreased handgrip strength before and after HSCT (P RESULTS:<RESULTS: 0.05).CONCLUSIONS:The donor type affects QOL, psychological status, and physical function in allo-HSCT recipients; these findings may provide insights for customised rehabilitation strategies for HSCT recipients. |
DOI | 10.1016/j.ejon.2015.02.002 |
PMID | 25911269 |