Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Not refereed |
Title | Mortality and morbidity in primarily resected hepatoblastomas in Japan: Experience of the JPLT (Japanese Study Group for Pediatric Liver Tumor) trials |
Journal | Formal name:Journal of pediatric surgery Abbreviation:J Pediatr Surg ISSN code:1531-5037(Electronic)0022-3468(Linking) |
Volume, Number, Page | 50(12),pp.2098-101 |
Papers・Author | Hiyama Eiso, Hishiki Tomoro, Watanabe Kenichiro, Ida Kohmei, Yano Michihiro, Oue Takaharu, Iehara Tomoko, Hoshino Ken, Koh Katsuyoshi, Tanaka Yukichi, Kurihara Sho, Ueda Yuka, Onitake Yoshiyuki |
Publication date | 2015/12 |
Papers・Description | BACKGROUND:In the Japanese Study Group for Pediatric Liver Tumor (JPLT) protocols (JPLT-1 and 2) for evaluating the cure rate of risk-stratified hepatoblastoma, primary resection was permitted in PRETEXT I and II cases, followed by postoperative chemotherapy.METHODS:In approximately 500 enrolled cases, resection was performed as the initial treatment in 60 cases, incMETHODS:luding all 18 PRETEXT I, 30 PRETEXT II, and 12 ruptured cases. The clinical features, surgical procedures, complications, and survival rates were compared in these three groups.RESULTS:All 18 PRETEXT I cases underwent complete resection by lobectomy or segmentectomy (n=14) or nonanatomical partial hepatectomy (NPH) (n=4). The 30 PRETEXT II cases underwent primary resection by right or left lobectomy (n=16), NPH (n=10), or other procedures (n=4). Of these 30 cases, operational death occurred in 1 newborn, and recurrence occurred in 7 cases (14.6%), including 6 NPH cases and 4 older cases (agedRESULTS:>RESULTS:3years). Of the 12 ruptured cases, 7 (58.3%) showed recurrence. Event-free survival rates at 5years in the 3 groups were 88%, 70%, and 32%, respectively.CONCLUSIONS:Primary resection for PRETEXT I or II HB cases should be performed by anatomical resection according to strict surgical guidelines. More intensified chemotherapy is required for primary resected cases whose tumors have ruptured. |
DOI | 10.1016/j.jpedsurg.2015.08.035 |
PMID | 26388131 |