Faculty Information |
|
Article types | Case report |
Language | English |
Refereed paper | Not refereed |
Title | Primary renal neuroblastoma with metastasis and matrix metalloproteinase-14 expression |
Journal | Formal name:Pediatrics international : official journal of the Japan Pediatric Society Abbreviation:Pediatr Int ISSN code:1442-200X(Electronic) |
Volume, Number, Page | 58(2),pp.161-4 |
Papers・Author | Zenitani Masahiro, Uehara Shuichiro, Miyashita Emiko, Hashii Yoshiko, Oue Takaharu, Okuyama Hiroomi |
Publication date | 2016/02 |
Papers・Description | UNASSIGNED:We herein report the rare case of a 4-year-5-month-old boy who presented with primary renal neuroblastoma. The patient developed repeated lung and liver metastatic recurrences, but, following a combination of chemotherapy, radiation therapy and aggressive surgical resection, the patient is now in remission. To investigate the pathogenesis of lung metastasis, immunohistochemistry was performed for matrix metalloproteinase-9 and -14 (MMP-9 and MMP-14), molecular markers of invasion, metastasis and angiogenesis in neuroblastoma. In the present case, MMP-9 expression was not observed, but MMP-14 expression was detected in the primary lesion and was more highly expressed in the metastatic lesion compared with the primary one. Given the MMP-14 staining in other cases, expression of MMP-14 may be associated with the aggressiveness of the tumor. This suggests that selected clones with high MMP-14 expression in the primary tumor might metastasize and form MMP-14-rich lesions. |
DOI | 10.1111/ped.12751 |
PMID | 26541120 |