Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Impact of Itraconazole After First-line Chemotherapy on Survival of Patients with Metastatic Biliary Tract Cancer |
Journal | Formal name:Anticancer research Abbreviation:Anticancer Res ISSN code:02507005/17917530 |
Volume, Number, Page | 35(9),pp.4923-4927 |
Papers・Author | Tsubamoto Hiroshi, Sonoda Takashi, Ikuta Shinichi, Tani Satoshi, Inoue Kayo, Yamanaka Naoki. |
Publication date | 2015/09 |
Papers・Description | AIM:
We evaluated the efficacy and safety of itraconazole after first-line chemotherapy in patients with metastatic biliary tract cancer (BTC). PATIENTS AND METHODS: We retrospectively reviewed data from patients with histologically-diagnosed BTC with distant metastases who had received one or more lines of chemotherapy and subsequent itraconazole chemotherapy. RESULTS: Among 28 enrolled patients, 26 (93%) received docetaxel (35 mg/m(2)), gemcitabine (1,000 mg/m(2)), and carboplatin (AUC4) on day 1 and oral itraconazole solution (400 mg) on days -2 to 2, repeated every 2 weeks. Two patients received docetaxel plus itraconazole with irinotecan. Two complete responses and 14 partial responses were observed, with a response rate of 57%. The median overall survival was 12.0 months. During 160 cycles, 21 (75%) and 17 (61%) patients had grade 3/4 neutropenia and thrombocytopenia, respectively. Two patients (7%) experienced febrile neutropenia. CONCLUSION: Combination chemotherapy with itraconazole after first-line chemotherapy is promising for patients with metastatic BTC. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
PMID | 26254389 |