Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | The Nonsteroidal Anti-inflammatory Drug Diclofenac Reduces Acid-Induced Heartburn Symptoms in Healthy Volunteers. |
Journal | Formal name:Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Abbreviation:Clin Gastroenterol Hepatol ISSN code:1542-7714(Electronic)1542-3565(Linking) |
Volume, Number, Page | 13(7),pp.1249-1255 |
Papers・Author | Kondo Takashi, Oshima Tadayuki, Tomita Toshihiko, Fukui Hirokazu, Okada Hiroki, Watari Jiro, Miwa Hiroto |
Publication date | 2015/07 |
Papers・Description | BACKGROUND & AIMS:We investigated the effects of diclofenac, a nonsteroidal anti-inflammatory drug that inhibits prostaglandin production, on induction of esophageal sensation by acid perfusion in healthy men.METHODS:We performed a prospective, double-blind, placebo-controlled, 2-period, cross-over study over 3 visits in 12 healthy men. Diclofenac was given 6 hours and 2 hours before an acid perfusion test. During the test, hydrochloric acid (0.15 mol/L) was perfused into the lower esophagus for 30 minutes; we evaluated upper gMETHODS:astrointestinal symptoms using a validated categoric rating scale. Then, we calculated and assessed the acid perfusion sensitivity score (APSS). Biopsy specimens were collected by endoscopy of the distal esophagus before and after acid perfusion; levels of prostaglandin E2 (PGE2) (pg/mg) were measured in the samples using an enzyme-linked immunosorbent assay.RESULTS:Compared with placebo, diclofenac significantly reduced the APSS for heartburn (82.2 ± 12.2 for placebo and 47.5 ± 8.9 for diclofenac; PRESULTS:<RESULTS:.01). Of the upper gastrointestinal symptoms, only the APSS for heartburn was reduced significantly by diclofenac. Compared with placebo, diclofenac reduced the overproduction of PGE2 by esophageal tissues after acid perfusion (23.3 ± 5.2 for placebo and 11.4 ± 3.5 for diclofenac; PRESULTS:<RESULTS:.05). APSS correlated with the development of heartburn and esophageal levels of PGE2 (r = 0.53; PRESULTS:<RESULTS:.05 for heartburn vs PGE2).CONCLUSIONS:Diclofenac attenuated acid-induced heartburn by inhibiting PGE2 overproduction in the esophagus. Esophageal PGE2 might be involved in producing heartburn symptoms. Clinical Trials Registry no: UMIN000014595. |
DOI | 10.1016/j.cgh.2015.01.014 |
PMID | 25632805 |