Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Effect of Intensive Statin Therapy on Coronary High-Intensity Plaques Detected by Noncontrast T1-Weighted Imaging: The AQUAMARINE Pilot Study. |
Journal | Formal name:Journal of the American College of Cardiology Abbreviation:J Am Coll Cardiol ISSN code:1558-3597(Electronic)0735-1097(Linking) |
Volume, Number, Page | 66(3),pp.245-56 |
Papers・Author | Noguchi Teruo, Tanaka Atsushi, Kawasaki Tomohiro, Goto Yoichi, Morita Yoshiaki, Asaumi Yasuhide, Nakao Kazuhiro, Fujiwara Reiko, Nishimura Kunihiro, Miyamoto Yoshihiro, Ishihara Masaharu, Ogawa Hisao, Koga Nobuhiko, Narula Jagat, Yasuda Satoshi |
Publication date | 2015/07 |
Papers・Description | BACKGROUND:Coronary high-intensity plaques detected by noncontrast T1-weighted imaging may represent plaque instability. High-intensity plaques can be quantitatively assessed by a plaque-to-myocardium signal-intensity ratio (PMR).OBJECTIVES:This pilot, hypothesis-generating study sought to investigate whether intensive statin therapy would lower PMR.METHODS:Prospective serial noncontrast T1-weighted magnetic resonance imaging and computed tomography angiography were performed in 48 patients with coronary artery disease at baseline and after 12 months of intensive pitavastatin treatment with a target low-density lipoprotein cholesterol level METHODS:<METHODS:80 mg/dl. The control group consisted of coronary artery disease patients not treated with statins that were matched by propensity scoring (n = 48). The primary endpoint was the 12-month change in PMR. Changes in computed tomography angiography parameters and high-sensitivity C-reactive protein levels were analyzed.RESULTS:In the statin group, 12 months of statin therapy significantly improved low-density lipoprotein cholesterol levels (125 to 70 mg/dl; p RESULTS:<RESULTS:0.001), PMR (1.38 to 1.11, an 18.9% reduction; p RESULTS:<RESULTS:0.001), low-attenuation plaque volume, and the percentage of total atheroma volume on computed tomography. In the control group, the PMR increased significantly (from 1.22 to 1.49, a 19.2% increase; p RESULTS:<RESULTS:0.001). Changes in PMR were correlated with changes in low-density lipoprotein cholesterol (r = 0.533; p RESULTS:<RESULTS:0.001), high-sensitivity C-reactive protein (r = 0.347; p RESULTS:<RESULTS:0.001), percentage of atheroma volume (r = 0.477; p RESULTS:<RESULTS:0.001), and percentage of low-attenuation plaque volume (r = 0.416; p RESULTS:<RESULTS:0.001).CONCLUSIONS:Statin treatment significantly reduced the PMR of high-intensity plaques. Noncontrast T1-weighted magnetic resonance imaging could become a useful technique for repeated quantitative assessment of plaq |
DOI | 10.1016/j.jacc.2015.05.056 |
PMID | 26184618 |