教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Factors associated with treatment outcome, and long-term prognosis of patients with ulcerative colitis undergoing selective depletion of myeloid lineage leucocytes: a prospective multicenter study. |
掲載誌名 | 正式名:Cytotherapy 略 称:Cytotherapy ISSNコード:1477-2566(Electronic)1465-3249(Linking) |
巻・号・頁 | 17(5),pp.680-8 |
著者・共著者 | Yokoyama Yoko, Watanabe Kenji, Ito Hiroaki, Nishishita Masakazu, Sawada Koji, Okuyama Yusuke, Okazaki Kazuichi, Fujii Hisao, Nakase Hiroshi, Masuda Tsutomu, Fukunaga Ken, Andoh Akira, Nakamura Shiro |
発行年月 | 2015/05 |
概要 | BACKGROUND:Patients with ulcerative colitis (UC) have elevated/activated myeloid lineage leucocytes and may respond favorably to adsorptive granulocyte/monocyte apheresis (GMA). However, there are patients who respond well to GMA, and patients who do not benefit. Therefore, predictive factors of GMA efficacy need to be defined.METHODS:In a prospective multicenter setting, 200 UC patients at 32 institutes received one GMA session per week over 10 weeks. Patients who achieved remission were followed for 12 months. The Clinical Activity Index (CAI) ≤3METHODS:meant remission, and response meant CAI decreased by ≥3. Quality of life was evaluated by the Inflammatory Bowel Disease Questionnaire (IBDQ).RESULTS:After final GMA, remission, response and no response rates were 67.0%, 15.0% and 18%, respectively. The remission group had a significant decrease in myeloid leucocytes and platelets. Corticosteroid dose decreased (P RESULTS:<RESULTS:0.001); 49 of 97 patients on corticosteroids became steroid-free. Baseline CAI was lower in the remission group versus non-remission (P RESULTS:<RESULTS:0.01), whereas IBDQ was higher in the remission group versus non-remission (P RESULTS:<RESULTS:0.05). After 12 months, 52 of 134 patients had maintained remission. Disease duration was longer in the relapsed group versus maintained remission group (P = 0.041). |
DOI | 10.1016/j.jcyt.2015.02.007 |
PMID | 25804800 |