教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Temporary dietary iron restriction affects the process of thrombus resolution in a rat model of deep vein thrombosis. |
掲載誌名 | 正式名:PloS one 略 称:PLoS One ISSNコード:1932-6203(Electronic)1932-6203(Linking) |
巻・号・頁 | 10(5),pp.e0126611 |
著者・共著者 | Oboshi Makiko, Naito Yoshiro, Sawada Hisashi, Hirotani Shinichi, Iwasaku Toshihiro, Okuhara Yoshitaka, Morisawa Daisuke, Eguchi Akiyo, Nishimura Koichi, Fujii Kenichi, Mano Toshiaki, Ishihara Masaharu, Masuyama Tohru |
発行年月 | 2015/05 |
概要 | BACKGROUND:Deep vein thrombosis (DVT) is a major cause of pulmonary thromboembolism and sudden death. Thus, it is important to consider the pathophysiology of DVT. Recently, iron has been reported to be associated with thrombotic diseases. Hence, in this study, we investigate the effects of dietary iron restriction on the process of thrombus resolution in a rat model of DVT.METHODS:We induced DVT in 8-week-old male Sprague-Dawley rats by performing ligations of their inferior venae cavae. The rats were then given either a normal diet (DVT group) or an iron-restricted diet (DVT+IR group). ThroMETHODS:mbosed inferior venae cavae were harvested at 5 days after ligation.RESULTS:The iron-restricted diet reduced venous thrombus size compared to the normal diet. Intrathrombotic collagen content was diminished in the DVT+IR group compared to the DVT group. In addition, intrathrombotic gene expression and the activity of matrix metalloproteinase-9 were increased in the DVT+IR group compared to the DVT group. Furthermore, the DVT+IR group had greater intrathrombotic neovascularization as well as higher gene expression levels of urokinase-type plasminogen activator and tissue-type plasminogen activator than the DVT group. The iron-restricted diet decreased intrathrombotic superoxide production compared to the normal diet.CONCLUSIONS:These results suggest that dietary iron restriction affects the process of thrombus resolution in DVT. |
DOI | 10.1371/journal.pone.0126611 |
PMID | 25962140 |