Faculty Information |
|
Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013. |
Journal | Formal name:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Abbreviation:J Infect Chemother ISSN code:1437-7780(Electronic)1341-321X(Linking) |
Volume, Number, Page | 21(5),pp.340-5 |
Papers・Author | Hamasuna Ryoichi, Yasuda Mitsuru, Ishikawa Kiyohito, Uehara Shinya, Hayami Hiroshi, Takahashi Satoshi, Matsumoto Tetsuro, Yamamoto Shingo, Minamitani Shinichi, Watanabe Akira, Iwata Satoshi, Kaku Mitsuo, Kadota Junichi, Sunakawa Keisuke, Sato Junko, Hanaki Hideaki, Tsukamoto Taiji, Kiyota Hiroshi, Egawa Shin, Tanaka Kazushi, Arakawa Soichi, Fujisawa Masato, Kumon Hiromi, Kobayashi Kanao, Matsubara Akio, Naito Seiji, Kuroiwa Kentaro, Hirayama Hideo, Narita Harunori, Hosobe Takahide, Ito Shin, Ito Kenji, Kawai Shuichi, Ito Masayasu, Chokyu Hirofumi, Matsumura Masaru, Yoshioka Masaru, Uno Satoshi, Monden Koichi, Takayama Kazuo, Kaji Shinichi, Kawahara Motoshi, Sumii Toru, Kadena Hitoshi, Yamaguchi Takamasa, Maeda Shinichi, Nishi Shohei, Nishimura Hirofumi, Shirane Takeshi, Yoh Mutsumasa, Akiyama Kikuo, Imai Toshio, Kano Motonori |
Publication date | 2015/05 |
Papers・Description | Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected frommale patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N. gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 μg/ml, and 11 (10.7%) strains were considered less susceptible with an MIC of 0.125 μg/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5 μg/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to other three fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin. The azithromycin MICs in 2 strains were 1 μg/ml. |
DOI | 10.1016/j.jiac.2015.01.010 |
PMID | 25727286 |