教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis. |
掲載誌名 | 正式名:World journal of gastroenterology : WJG 略 称:World J Gastroenterol ISSNコード:2219-2840(Electronic)1007-9327(Linking) |
巻・号・頁 | 21(6),pp.1880-6 |
著者・共著者 | Kawakami Ken, Inoue Takuya, Murano Mitsuyuki, Narabayashi Ken, Nouda Sadaharu, Ishida Kumi, Abe Yosuke, Nogami Koji, Hida Nobuyuki, Yamagami Hirokazu, Watanabe Kenji, Umegaki Eiji, Nakamura Shiro, Arakawa Tetsuo, Higuchi Kazuhide |
発行年月 | 2015/02 |
概要 | AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis (UC) patients.METHODS:This was a prospective, multicenter, observational study. Between May 2010 and August 2012, 49 steroid-refractory UC patients (55 flare-ups) were consecutively enrolled. All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1 mg/kg per day. TMETHODS:he dose was adjusted to maintain trough whole-blood levels of 10-15 ng/mL for the first 2 wk. Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger's clinical activity index (CAI).RESULTS:The mean CAI was 12.6 ± 3.6 at onset. Within the first 7 d, 93.5% of patients maintained high trough levels (10-15 ng/mL). The CAI significantly decreased beginning 2 d after treatment initiation. At 2 wk, 73.1% of patients experienced clinical responses. After tacrolimus initiation, 31.4% and 75.6% of patients achieved clinical remission at 2 and 4 wk, respectively. Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation. Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. |
DOI | 10.3748/wjg.v21.i6.1880 |
PMID | 25684955 |