教員業績データベース |
|
論文種別 | その他 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | High-dose regimen to achieve novel target trough concentration in teicoplanin. |
掲載誌名 | 正式名:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 略 称:J Infect Chemother ISSNコード:1437-7780(Electronic)1341-321X(Linking) |
巻・号・頁 | 20(1),pp.43-7 |
著者・共著者 | Ueda Takashi, Takesue Yoshio, Nakajima Kazuhiko, Ichki Kaoru, Wada Yasunao, Komatsu Miyuki, Tsuchida Toshie, Takahashi Yoshiko, Ishihara Mika, Kimura Takeshi, Uchino Motoi, Ikeuchi Hiroki |
発行年月 | 2014/01 |
概要 | In the treatment of severe MRSA infections such as endocarditis, more than 20 mg/L of plasma trough concentration (C(min)) is recommended for teicoplanin; however, in the treatment of common MRSA infections, recommended C(min) remains more than 10 mg/L. In this study, we set C(min) as 15-30 mg/L to obtain a favorable clinical outcome in the treatment of common MRSA infections, and investigated the optimal loading regimen that achieved the target C(min) in patients with normal renal function. Seventy-eight patients received the high-dose regimen A (6 mg/kg every 12-h for initial two days) and 60 patients received the high-dose regimen B (the first five loading doses of 10-12 mg/kg at 12-h intervals for initial three days, followed by 6 mg/kg once daily). The mean C(min) on the 4th day was 13.7 ± 5.3 mg/L in regimen A, and 20.0 ± 6.6 mg/L in regimen B (P<0.001), and the proportion of patients achieving the 15-30 mg/L was 25.6% and 68.3% (P<0.001). Clinical response at end-of treatment were 66.7% and 85.0% (P = 0.014). The patients of initial C(min) with ≥15 mg/L had tended to be higher clinical response than those with<15 mg/L (80.9% vs 68.6%, P = 0.084). There were no significant differences in the occurrence of adverse effects in regimen A and B (nephrotoxicity; 1.3% vs 3.3%, P = 0.413, hepatotoxicity; 5.1% vs 3.3%, P = 0.608). In conclusion, to obtain C(min) 15-30 mg/L, the first five loading doses of 10-12 mg/kg at 12-h intervals was required in patients with normal renal function. |
DOI | 10.1016/j.jiac.2013.08.006 |
PMID | 24462424 |