教員業績データベース |
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論文種別 | その他 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Antibiotic susceptibility surveyof blood-borne MRSA isolates in Japan from 2008 through 2011. |
掲載誌名 | 正式名:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 略 称:J Infect Chemother ISSNコード:1437-7780(Electronic)1341-321X(Linking) |
巻・号・頁 | 20(9),pp.527-34 |
著者・共著者 | Hanaki Hideaki, Cui Longzhu, Ikeda-Dantsuji Yurika, Nakae Taiji, Honda Junichi, Yanagihara Katsunori, Takesue Yoshio, Matsumoto Tetsuya, Sunakawa Keisuke, Kaku Mitsuo, Tomono Kazunori, Fukuchi Kunihiko, Kusachi Shinya, Mikamo Hiroshige, Takata Tohru, Otsuka Yoshihito, Nagura Osanori, Fujitani Shigeki, Aoki Yosuke, Yamaguchi Yoshio, Tateda Kazuhiro, Kadota Junichi, Kohno Shigeru, Niki Yoshihito |
発行年月 | 2014/09 |
概要 | We conducted an antibiotic susceptibility survey of 830 blood-borne methicillin resistant Staphylococcus aureus collected from nationwide hospitals in Japan over a three-year period from January 2008 through May 2011. Antibiotic susceptibility was judged according to the criteria recommended by the Clinical Laboratory Standard Institute. Over 99% of the MRSA showed to be susceptible to teicoplanin, linezolid, sulfamethoxazole/trimethoprim and vancomycin, and over 97% of them were susceptible to daptomycin, arbekacin and rifampin. The majority of the MRSA strains showed resistant to minocycline, meropenem, imipenem, clindamycin, ciprofloxacin, cefoxitin, and oxacillin in the rates of 56.6, 72.9, 73.7, 78.7, 89.0, 99.5, and 99.9%, respectively. Among the MRSA strains, 72 showed reduced susceptibility to vancomycin, including 8 strains (0.96%) of vancomycin-intermediate S. aureus (VISA), 54 (6.51%) of heterogeneous vancomycin-intermediate S. aureus (hVISA), and 55 (5.63%) of β-lactam antibiotics-induced vancomycin resistant S. aureus (BIVR). Unexpectedly, among the 54 hVISA and 55 BIVR, 45 isolates (83.3% and 81.8%, respectively) showed both hVISA and BIVR phenotypes. A new trend of vancomycin resistance found in this study was that VISA strains were still prevalent among the bacteremic specimens. The high rates of the hVISA/BIVR two-phenotypic vancomycin resistance, and the prevalence of VISA in the bloodborne MRSA call attention in the MRSA epidemiology in Japan. |
DOI | 10.1016/j.jiac.2014.06.012 |
PMID | 25066429 |