教員業績データベース |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読なし |
表題 | Meniscus regenerationby syngeneic, minor mismatched, and major mismatched transplantation of synovial mesenchymal stem cells in a rat model. |
掲載誌名 | 正式名:Journal of orthopaedic research : official publication of the Orthopaedic Research Society 略 称:J Orthop Res ISSNコード:1554-527X(Electronic)0736-0266(Linking) |
巻・号・頁 | 32(7),pp.928-36 |
著者・共著者 | Okuno Makiko, Muneta Takeshi, Koga Hideyuki, Ozeki Nobutake, Nakagawa Yusuke, Tsuji Kunikazu, Yoshiya Shinichi, Sekiya Ichiro |
発行年月 | 2014/07 |
概要 | We compared the effect of syngeneic and allogeneic transplantation of synovial mesenchymal stem cells (MSCs) for meniscus regeneration in a rat model. Synovium was harvested from the knee joints of three strains of rats. The anterior half of the medial meniscus in both knees of F344 rats was removed and 5 million synovial MSCs derived from F344 (syngeneic transplantation), Lewis (minor mismatched transplantation), and ACI (major mismatched transplantation) were injected into the knee of the F344 rats. At 4 weeks, the area of the regenerated meniscus in the F344 group was significantly larger than that in the ACI group. Histological score was significantly better in the F344 and Lewis groups than in the ACI group at 8 weeks. DiI labeled cells could be observed in the knee joint in the F344 group, but were hardly detected in the ACI group at 1 week. The number of macrophages and CD8 T cells at synovium around the meniscus defect was significantly lower in the F344 group than in the ACI group at 1 week. Syngeneic and minor mismatched transplantation of synovial MSCs promoted meniscus regeneration better than major mismatched transplantation in a rat meniscectmized model. |
DOI | 10.1002/jor.22614 |
PMID | 24644154 |