Faculty Information |
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Article types | Original article |
Language | English |
Refereed paper | Refereed |
Title | Expression of parathyroid hormone/parathyroid hormone-related peptide receptor 1 in normal and diseased bladder detrusor muscles: a clinico-pathological study. |
Journal | Formal name:BMC urology Abbreviation:BMC Urol ISSN code:1471-2490(Electronic)1471-2490(Linking) |
Volume, Number, Page | 15(1),pp.2 |
Papers・Author | Nishikawa Nobuyuki, Yago Rie, Yamazaki Yuichiro, Negoro Hiromitsu, Suzuki Mari, Imamura Masaaki, Toda Yoshinobu, Tanabe Kazunari, Ogawa Osamu, Kanematsu Akihiro |
Publication date | 2015 |
Papers・Description | BACKGROUND:To investigate the expression of parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor 1 (PTH1R) in clinical specimens of normal and diseased bladders. PTHrP is a unique stretch-induced endogenous detrusor relaxant that functions via PTH1R. We hypothesized that suppression of this axis could be involved in the pathogenesis of bladder disease.METHODS:PTH1R expression in clinical samples was examined by immunohistochemistry. Normal kidney tissue from a patient with renal cancer and bladder specimens from patients undergoing ureteral reimplantation for vesicoureteral reflux or partial cy |
DOI | 10.1186/1471-2490-15-2 |
PMID | 25604159 |